Monthly Archives:January 2017
Assessment of cognitive and emotional function in humans: insight from simultaneous scalp and deep brain recording techniques
There are several techniques for monitoring and recording brain activity that do not require cutting tissue or putting devices inside the brain. For example electroencephalography, magnetoencephalography and the functional magnetic resonance imaging are all non-invasive techniques to
Stress, sex, and sunlight – a different perspective on vitamin D
Low levels of vitamin D in the blood have been associated with a high risk of developing several diseases, including autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, and cancer. Our study group has been working on the role
TRIM32 and alpha-synuclein: a novel interplay in the neuronal system
帕金森病(PD)是第二个最common neurodegenerative disease mainly characterised by the progressive loss of nigrostriatal dopaminergic neurons, resulting in a series of motors symptoms and the formation of intracellular inclusions within the cells, known
Enzymes digestible nanoparticles: a new generation of biodegradable drug delivery nanosystem
Pathologies with high death rates such as cancers may well have found their solutions with the rise of nanotechnology. Nanotechnology is a newly coined word encompassing the application of nanoparticles for all kinds of technological challenges. A
The impact of erythrocyte-derived microvesicles on hemostatis disorder during burn injury
微粒或微泡(MVs)关闭fragments of cell membranes, released into the blood flow by different types of cells, such as: erythrocytes, platelets, white blood cells and endothelial cells. It has been proved that MVs play
Novel perspectives for the Alzheimer´s disease therapy in a multitargeted approach
Alzheimer´s disease (AD) is the most wide-spread neurodegenerative disease and develops to a main problem for a society in which the people get older and older as a result of improved drug developments and therapies. The benefit
Pre-market chemical risk assessment is controlled entirely by industry
A chemical’s manufacturer provides essentially all the data for most (pre-market) chemical risk assessments (RA); academics study a chemical only once it is marketed. For two randomly-chosen high production chemicals, despite new European Union mandates to evaluate
Seeing the world in three dimensions, fast-but-rough and slow-but-accurate
When we perform a task, there is generally the tradeoff between the time taken to achieve the goal and the quality of the attained result. For example, when we solve a mathematical problem, we can quickly perform
Chronic lymphocytic leukemia (CLL) diagnostics better to do in cultivated than native cells
Cancer is an age associated disease. In Western countries with people having longer life expectancies than e.g. 100 years ago, this means at present that 1-2% of those individuals are confronted with the diagnosis of leukemia during
ACTH deficiency in patients with suspected hypopituitarism: Choosing the right diagnostic test
The pituitary gland is a pea-sized gland located at the base of the brain. Often termed the “master-gland”, it secretes hormones which control growth, metabolism and fertility. Hypopituitarism is a clinical syndrome of deficiencies in one or
Treating nonsense may be a cure for the blinding disease Choroideremia
Choroideremia (CHM) is a blinding genetic eye disease, where male children as early as 5 years old develop night-blindness, followed by loss of their peripheral field of vision in adolescence, culminating in complete blindness in late adulthood.
Nitrogen limitation of CO2 fertilization: relief from fungal partners
New research shows that the stimulatory effect of atmospheric CO2 on plants depends on soil nitrogen and on the microbes that can help plants get it. It’s common knowledge in horticulture that pumping extra carbon dioxide into
Reducing cellular stress may prevent diabetes complications
Poorly controlled diabetes is often associated with various complications including blindness, kidney failure and pain secondary to damaged nerves. However, the most common complications are those related to large blood vessel disease such as heart attacks and
Estimates of the impact of a new drug on US health care budgets: are published studies done well?
An analysis to estimate the impact of a new drug on health care budgets (budget impact analysis) is desired by many US health plans before adding a new drug to their formulary and providing insurance coverage. However,
Uncomplicated type B acute aortic dissection: endovascular repair or best medical treatment?
Patients with uncomplicated type B acute aortic dissection (type B-AAD) are commonly treated with conservative therapy (best medical treatment [BMT]) although the long-term outcome of medical therapy alone is suboptimal, with a reported 30% to 50% mortality
Training the next generation of global health leaders in the Pacific Rim
Global health is the term applied to a rapidly growing area of research, training, and application of public health approaches on a global scale. The solutions to current and future global health problems will require a highly-trained,
Molecular cardiology: refocusing on diastolic (dys)function
The pumping of the heart consists of alternate contractions (systole) and relaxations (diastole). The inability of the left ventricle (LV) to eject (systolic dysfunction) or fill (diastolic dysfunction) blood most frequently leads to heart failure (HF) with
A highly flexible and stretchable energy storage device
With rapid development of portable and wearable electronics, highly flexible and stretchable energy conversion and/or storage devices are required to be used as power sources. As one of the most important energy storage devices, supercapacitors (also called
Lessons from a small outbreak of poliomyelitis
The campaign to eradicate poliomyelitis, a paralytic viral neuroinfection, launched by the World Health Organization (WHO) in 1988, resulted in the drop of the disease incidence from several hundred thousands cases per year to less than one
