Yearly Archives:2015
Computational refinement and validation protocol for proteins
HIV protects itself using a membrane layer of lipids which covers all proteins which could potentially be targeted by drugs. The only exposed proteins, gp120 and gp41 form spikes that protrude out of the lipid membrane. These
Janus subcompartmentalized microreactors
When we are sick and have to take medicine, the first thing we do, is reading the package leaflet. We want to know the potential side effects of the drug. Sometimes the side effect of one drug
Nuclear membrane diversity
Although it is obvious that every tissue in our bodies is different, the vast majority of scientific research is done on a small number of cancer cell lines studying individual cells grown in dishes — for example
Person centered progressive resistance exercise for women with fibromyalgia
Muscle strength in women with fibromyalgia (FM) is reduced compared to healthy women and a reason for this might be a low level of physical activity at such intensity that is required to maintain or improve muscle
Is it possible reversible and irreversible aggregation of proteins?
The discovery of protein chain regions responsible for protein aggregation is an important result of studying of the molecular mechanisms of prion diseases, and different proteinopathies associated with the formation of pathological aggregations through the prion mechanism.
Human centromeric DNA is able to form quadruplex helices
大多数的染色体的经典视图of people have in mind is a cross-shaped figure, something like the letter X. Chromosomes look indeed like that when the cell is ready to divide and give rise
How to know transcription factors by the company they keep
The ENCODE project is a massive data-collection effort set out to understand the function of the human genome. The collection comprises many types of genomic data, including the localization of transcription factors onto DNA. Transcription factors are
Allergy: the latest technology in vitro in the service of an appropriate diagnosis
The countless and various allergen sources from both the plant kingdom is to the animal kingdom constantly stimulate our immune system.So the allergy diagnostics laboratory is evolving using new technologies such as molecular biology, nanotechnology to highlight
Cerium loading into Zr-Metal Organic Frameworks, a new strategy for redox catalysis
Porous solids are a class of material with high scientific and technological significance. Porosity permits molecules to access the surface and the bulk of the solid. MOFs or Metal-Organic Frameworks are hybrid organic/inorganic materials that are the
The infusion of haematopoietic stem cells in patients with liver insufficiency
Cirrhosis, the end result of long-term liver damage, and its related morbidity represnt a significant burden on health care worldwide. Liver transplantation is the only definitive therapeutic option for those patients. However, the paucity of donors, the incidence
What type of immune responses are needed to control HIV infection?
Human immunodeficiency virus-1 (HIV-1) infection can be controlled by antiretroviral therapy (ART) for long periods of time, preventing the development of HIV-induced immunodeficiency and AIDS. However, HIV-1 infection cannot be eradicated from immune cells by ART and
Can we help infertile couple suffering from in vitro fertilization arrest with ca2+ ionophore?
Intracytoplasmic sperm injection (ICSI) is an infertility treatment technique developed to help infertile couples to conceive child. ICSI is performed by injecting one spermatozoon (male gamete) into cytoplasm of an oocyte (female egg) in vitro in assisted
Antibiotic sensing by a bacterial communication system
Bacteria compete using antibiotics. Bacteria compete with one another using an array of destructive compounds and strategies. For example antibiotics, used to treat infections, are produced by bacteria and other microbes and can kill competitors in mixed
Alzheimer’s disease: SMILES to preserve wisdom
Simplified molecular input-line entry systems (SMILES) is informative representation of molecules. This representation gives possibility to compare molecules in their architecture and in their action. Molecules characterized by good pharmaceutical action can be modified in order to
Road traffic noise linked to deaths and increased risk of stroke
Traffic noise is a known environmental risk factor for health. Health effects of noise exposure are hypothesised to occur via several pathways. Exposure to noise may affect the autonomic nervous system increasing heart rate, blood pressure and
‘Fossil’ DNA – How many observed soil bacteria are actually alive?
In the first half of the 20th century, researchers studying soil bacteria had a problem: the number of organisms they could grow in the lab only accounted for ~1% of the total population that they could see under
Science and religion reconciled by the Information concept
In general, evolution is the process by which complexity arises from relative simplicity, and science sees no need to start the process with complexity, which religious people translate as “God.” However, science is increasingly recognizing an abstract
Diagnosis and management of bile leaks after hepatectomy
One of the most common complications of hepatic resection is biliary leak, which may happen from the cut-surface of the liver that is made by the surgeon during the operation. Biliary leak may be an important source
To beam or not to beam: Safely scanning mouse lungs for lung disease and therapy research
Lung diseases are among the most important causes of sickness and death in the world. Chronic obstructive pulmonary disease, lung fibrosis and emphysema are examples of such devastating and life-threatening conditions. Doctors can help by relieving symptoms,
Organic semiconductors for future photovoltaics
Organic semiconductors based photovoltaics devices are able to absorb light of different wavelengths and converted it into electricity or electrical signal. By converting the light into electricity, the organic solar cells represent a clean, cost-effective and easy
