Tag Archives:inflammation
Aorta tertiary lymphoid organs: Powerhouses of B cell immunity in atherosclerosis
Cardiovascular disease (CVD) is the leading cause of death worldwide. Yet, our understanding of how the immune system impacts CVD is very limited and immune system-based therapeutic approaches are not in sight. Lymphocytes are major cellular constituents
Inflammation alters brain function and pain processing centrally
In the last couple of years, some fascinating abilities of the immune system have emerged: The immune system is tightly interconnected with the nervous system, and can directly affect how the brain functions, and how a person
Modulation of SOCS3 in macrophages can enhance the clearance of dying cells in inflammation
Macrophages, from the Latin meaning “big eaters”, are key cells of the immune system that have the ability to scan tissues in the body and engulf and destroy invading pathogens. They also play a housekeeping role, to
Immunological disturbances observed in chronic alcoholism
Alcoholism is a complex behavioral disorder characterized by the loss of control over alcohol consumption often involving other drug abuse with a relapsing and remitting course leading to significant impairment. Chronic alcohol use and alcoholism damages many
Can Radon radiation become a source of treatment for Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is the most common type of autoimmune disease. It is triggered by a faulty immune system of the body. However, the real cause of the disease is not completely known. The disease affects the
Orphans and inflammation
Many are now well-aware of the negative impact of inflammation on our health, including cancer as well as rheumatologic, metabolic and neurologic disorders. Insults to the body either through injury (acute or chronic), or poor diet can
微调的炎症是成功的关键limb regeneration
Complete regeneration of appendages after amputation in certain fish and amphibians has long served as a useful model for analyzing why regeneration is unsuccessful in most mammalian organs. Recent work with zebrafish, frog tadpoles, salamanders, reviewed in
HIV/AIDS-associated tryptophan depletion as part of the influence of inflammatory mediators on general nutritional status
The essential amino acid tryptophan cannot be synthesised in the body and must be acquired through dietary intake. Tryptophan is an important substrate for protein synthesis and for synthesis of the neuroactive substances serotonin, melatonin and tryptamine.
The inflamed skin in atopic eczema contributes to the disrupted skin-barrier
Atopic dermatitis, also known as atopic eczema or neurodermitis, is a chronic allergic skin disease affecting 15 – 30 % of children and 2 – 10 % of adults in industrialized countries. Patients suffer from inflamed, red
Understanding the rare disease alkaptonuria: the role of oxidative stress, inflammation and amyloidosis
Alkaptonuria (AKU) is an ultra-rare disease that was recognized among the first inborn errors of metabolism. In AKU, an altered activity of the enzyme homogentisate 1,2-dioxygenase (HGD) occurring upon gene mutation lead to a defective metabolism of
The many faces of macrophages in lung cancer
Lung cancer is the leading cause of cancer death worldwide, accounting for more deaths than breast, prostate, and colon cancer combined. Within the past decade, the role of the immune system in the development and progression of
ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling
Cardiovascular diseases are disorders of the heart and blood vessels which are leading to heart failure. Cardiovascular diseases correspond to 30% of all deaths in the world. The molecular processes that undergone from a healthy heart to
How the immune system is regulated by small RNAs called microRNAs to prevent self-attacks leading to autoimmunity
The ability to properly engage the different arms of the immune response is essential for protection from pathogens but also for preventing autoimmune reactions against normal tissue. Central to autoimmune prevention are a class of white blood
Blocking miR-212/132 in T cells is a potential therapy for treating colitis
Inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis, is thought to be caused by aberrant immune response to host intestinal microbiota, leading inflammation in gastrointestinal tract. The symptoms such as diarrhea, rectal bleeding, anemia,
More reasons to appreciate the Golden Spice “saffron”
Cancer remains a leading cause of morbidity and death worldwide. What is even worse is that the number of new cancer cases is projected to massive increase which would probably make it the first cause of death
In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa
Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring the pro-inflammatory capability of bacterial virulence factors in vivo is challenging and usually requires invasive methods. The
Updates on the pathophysiology of systemic sclerosis
Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with autoimmune component, inflammation, and progressive fibrosis of conjunctive tissues of the skin and internal organs. Lung involvements are a major cause of concern as pulmonary fibrosis and
Recharged autologous stem cells to combat cartilage defects in osteoarthritic patients
Inflammation is one of the greatest challenges for physicians and researchers working to find new strategies to regenerate patients’ damaged and deteriorated cartilage. Although humans have stem cells which can aid in many tissue repair processes throughout
Obesity protects inflamed dialysis patients
A high body mass index (BMI) is linked to longer survival terms for several serious chronic debilitating diseases. A large European epidemiological study shows that this protective effect does not apply to all patients with a high
