Tag Archives:drug
Hot or Not – The Heat Shock Factor1 (HSF1) is essential for Candida albicans cellular functioning
The opportunistic human pathogen, Candida albicans hinges on the heat shock factor-1 (HSF1), a client protein of the well-established heat shock chaperone (protein folding helper), HSP90 for proficiently modulating thermal stress response. In addition to its implications
Applying nanopharmacology to obstetrics: A novel targeted drug delivery system for the uterus
Pregnancy is a dangerous period for both the mother and foetus. Being born too early (preterm birth) is the leading cause of death and disease in children <5 years of age, while insufficient uterine contractions during or
Gold-silver nanoparticles instead of traditional diabetic drugs
Recently, we have published a pioneering work on green biosynthesis and complete characterization of gold and core shell silver-gold nanoparticles (AuNPs and Ag@AuNPs) via using green biopolymer in the influence of microwave radiation. These synthesized nanoparticles provide
3rd International Conference and Expo on Drug Discovery & Designing. Vienna, Austria. October 02-04, 2017
Conference Series has taken an initiation to conduct international conference and Expo on Drug Discovery & Designing workshops worldwide . From last 3 years Conference Series has been conducting Drug Discovery & Designing conferences in major continents
Artemisia annua leaves improved solubility of antimalarial drug, artemisinin
Artemisia annua L., also known as Sweet Annie, is a Chinese medicinal herb that produces the important antimalarial drug, artemisinin. Artemisinin is the most powerful antimalarial ever discovered and its derivatives are the main component of artemisinin
Simple mathematical formulas for tracking the number of antibiotic resistance cases globally
In order to continue to live, microbes and germs have found ways to prevent drugs from killing them in the process of curing patients—when the patients ingest the drugs for treatment. Microbes destroying drugs within patients and
Glutathione-responsive co-assembly hydrogel for controllable drug release
Glutathione-responsive nano-vehicles have gained considerable interest because several intracellular compartments such as cytosol, mitochondria, and cell nucleus contain a high concentration of glutathione (GSH, 2-10 mM) tripeptides, which is 100-1000 times higher than that in extracellular fluids
Are less expensive “biosimilar” drugs as effective at treating ankylosing spondylitis?
Ankylosing spondylitis (AS) is a type of arthritis caused by inflammation, in which the main symptom is back pain. When a substance called tumour necrosis factor (TNF) is over-active in the body, it causes inflammation and damage
Can a doughnut-shaped molecule help design new drugs?
Some of the most advanced and modern medicines, such as those used in the treatment of cancer rely heavily on their selective, high affinity targeting of cancerous cells in order to be effective medicine. However, some drugs
Clues for innovative therapies targeting the c-ring of the F1FO-ATP synthase
Increasing evidence points out that the ATP synthase/hydrolase, also known as F1FO-complex, can be the key enzymatic switch between cell life and death. So, the enzyme complex, which bears the task of building most cellular ATP, the
A new drug target for healthful aging
With the aging population of the United States increasing every year, there is an increasing need to develop new therapeutic modalities to provide for healthful aging. Although longevity is generally considered positively in most families, and of
Special molecular mechanism makes CD147 an interesting drug target in cancer or autoimmune diseases
T cells are important players of the immune system, recognizing foreign or dangerous agents with their unique receptors. They defend the body from these agents either directly by killing or by recruiting or regulating other immune system
An international team opens new avenues toward PKU therapy
When a baby is born, a simple blood test reveals whether the child has PKU, which is a recessive genetic disorder where the body fails to regulate the amount of phenylalanine (Phe) in blood. Phe is a
The apothecary inside us
New drugs might be found right under our noses or, more precisely, in our guts as we learn more about the ways metabolites from intestinal bacteria modulate human metabolic and immunity pathways. Our recently published paper in
Using computers to understand the deposition of pollutant and therapeutic aerosols in the human lungs
In an urban setting, suspended pollutant particles enter our lungs along with air we inhale. A good portion of them gets deposited on our airways, often inducing toxic effects. A young child or an elderly patient facing
Continuing the age of discovery in cardiovascular disease
A rare genetic defect involving the heart muscle is leading to early heart failure and potentially lethal heart rhythms for patients in Saudi Arabia. This disease, called Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia or ARVC/D, involves healthy heart muscle
Prompt resolution of essential drug intolerance
The gut is nowadays seen as a site of cross-talk and interchange between the inner body (supposed to be sterile, namely free of viable harmful bugs) and the outer contaminated world, mainly entering the digestive tract through
Drugs and drowning
Electrical activity of the heart is commonly monitored by the electrocardiogram (ECG). Such electrical activity depends on certain proteins called ion channels. These channels control the timing and the flow of electrically charged particles (ions) in and
Improving nature’s own communication system to fight cancer
Our bodies are composed of trillions of different cells, which communicate with each other in order to keep us healthy. There are several ways in which messages can be sent back and forth between cells. One of
A promising novel drug for breast cancer
The reason cancer is so difficult to treat is that cancer cells are our own cells running wild, which means that they generally do not make any protein or other molecule that normal cells don’t make. This
