Tag Archives:protein
Participation of secreted protein L5 in formation of outer membrane vesicles produced by Lysobacter sp. XL1
Formation of outer membrane vesicles is a physiological feature of Gram-negative bacteria. Vesicles formation is result of splitting off the evagination of bacterial outer membrane. Its size varies from 20 to 300 nm. During formation of vesicles,
A Tat ménage a trois – when it comes to Tat secretion two Tat’s are essential, but the third one makes it that much better
The membrane is the cellular barrier that keeps the inside of a cell separate from the outside, but in order to survive molecules and proteins do need to cross this barrier. Water and small molecules can do
Can we create easy-to-use software to capture the complex behaviors of proteins?
Proteomics is the large-scale study of proteins enabled by mass spectrometry technology. Much like a fingerprint can place someone at a scene despite the lack of an eye witness, a mass spectrometer records protein fingerprints that are
How do microorganisms survive in extreme conditions?
You may have taught how extreme regions like glaciers, mountains, and deep oceans are habitats for many organisms including bacteria, archaea, algae, and yeasts as well as glaciers ice worms, plants and animals. These organisms survive in
Predictors of 360-day survival in centenarians
Healthy aging assumes the combination of longevity and quality of life. Quality of life in old age is associated with mental and physical well-being allowing for independent living and social function. Appropriate scales can be used to
Cold denaturation
Most proteins can be thought like beady chains which form compact well-ordered coils whose surface protects the greasy-like interior from the contact with water molecules. We are studying what are the forces which keep the coil compact.
Why do older people get so much kidney disease?
To celebrate Sir William Osler’s 70th Birthday on July 12th 1919 his pupils and co-workers contributed scientific articles that were collected and published. One of these articles, by William Councilman pathologist-in-chief at Peter Bent Brigham Hospital, noted
Mass spec: a powerful weapon in the battle against illegal polypeptide drugs
The occurrence of illegal medicines is a well-established global problem and concerns mostly small molecules (Molecular weight below 900 Da), including sildenafil (active pharmaceutical ingredient of Viagra® and Cialis®) and analogues, anti-biotics, HIV medication, anti-malaria products, anabolic
Understanding the evolution of protein dynamics can lead to more effective non-toxic drug therapies
Proteins are macromolecules that play important roles in all living organisms. They protect the body from viruses and bacteria, control chemical reactions, transmit signals between cells and organs, and transport other molecules to places in the body
Two views on the protein folding puzzle
Protein chain folding is a miracle. The protein chain is gene-encoded and initially has no structure (Fig. 1, left panel). Its intricate structure (Fig. 1, right), with every atom in its unique position, results from spontaneous folding.
Protein expression is useful to screen high risk patients for cancer
Endometrial cancer is the most common type of uterine cancer in the United States. The American Cancer Society estimates 54,870 newly diagnosed endometrial cancer cases and 10,170 deaths caused by endometrial cancer in 2015. Most patients (~80%) have a subtype called
Producing recombinant proteins for human use
Chinese Hamster Ovary (CHO) cell lines are the most frequently used cell lines in the biopharmaceutical industry for the production of therapeutic recombinant proteins, because they can be easily genetically manipulated, grow quickly, can be easily adapted
Heme: an old player with a novel mechanism in cardiac muscle contractility
Heme is a complex containing iron and protoporphyrin IX and it is commonly bound to proteins involved in oxygen transport, detoxification and energy production. However, this molecule has been known to have toxic effects in the heart.
Regulation of mediator’s expression and chemotaxis in mast cells
The increasing prevalence of inflammatory diseases worldwide underlines the importance to study the molecular mechanisms leading to these disorders. Recent genome-wide association studies based on large group of patients and healthy controls revealed candidate genes, which are
A novel protein called nischarin
Nischarin is a large protein that is present in the nucleus and cytoplasm of cells. So far, diseases associated with the NISCH gene include hypertension, dry mouth, morphine dependence, depression, anxiety, thick heart walls, congestive heart failure,
Stress tolerance in plants is controlled by a “master regulator” of chloroplast protein import
To achieve food security by meeting the needs of an ever growing human population, which could reach near 10 billion by 2050, large increases in crop yields will be essential. Environmental stresses, such as drought and salinity,
Effects of whey protein on strength, fat free mass or lean body mass
Protein supplementation has become common practice for many competitive and recreational athletes. Since a variety of protein sources and multi-ingredient formulations are marketed, athletes and nutritional coaches would need to know more on the effectiveness of such
New separation principle of proteins by liquid chromatography resulting in ultrafast high-resolution separation
The purpose of separation science is to isolate some useful substances from natural and/or synthesized products to serve for human society. An ideal separation method is to have the feature of “three high” of high resolution (quality),
