Tag Archives:tumor microenvironment
Skewed signaling through RAGE strength the tumor growth-promoting activities of M2 macrophages
Tumors are complex tissues composed by both non-cellular components, mainly matrix proteins, and different stromal cell types, which are under an active cross talk with tumor cells. Tumor-associated macrophages (TAMs) are the major leukocyte population among the
The mechanisms of MCP-1 production in tumor microenvironments: Tumor cells are not home alone
When you look at tumors, you may think they are composed of 100% tumor cells. The fact is that tumor tissues contain not only tumor cells but also a variety of non-tumor stromal cells, including fibroblasts, endothelial
Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies
Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the
Focusing on non-tumor-derived factors for leukemia therapy
Approximately 10-20 million people worldwide are estimated to be infected with human T-cell leukemia virus type I (HTLV-I), and 1-3% of HTLV-I-infected individuals develop a cancer of CD4+ T lymphocytes in the blood each year. The retrovirus-associated
