Tag Archives:细胞周期蛋白
Gastrointestinal stromal tumor transition to KIT-independence is enabled by a Cyclin D1 dependent proliferation program
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. GISTs generally contain oncogenic gain-of-function KIT (~85%) or PDGFRA (~5-10%) mutations which are crucial for GIST proliferation and survival, as underscored by the
A synthetic natural like product endowed with antiproliferative activity
The World Health Organization has reported that cancer is one of the major causes of morbidity and mortality affecting population in all countries and regions. The 2014 World Cancer Report of WHO indicated that in 2012 there
A better understanding of cell division by combining mathematical modeling and experimentation
The cell division cycle is the process by which a growing cell replicates its genome and partitions the two copies of each chromosome to two daughter cells at division. It is of utmost importance to the perpetuation
