Tag Archives:cyclin D1
Gastrointestinal stromal tumor transition to KIT-independence is enabled by a Cyclin D1 dependent proliferation program
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. GISTs generally contain oncogenic gain-of-function KIT (~85%) or PDGFRA (~5-10%) mutations which are crucial for GIST proliferation and survival, as underscored by the
