Tag Archives:DNA methylation
miRNA, the inconspicuous but key player in the development of cervical cancer
Cervical cancer is among the top three cancers affecting women below 45 years in several countries. Both the alterations and modification in deoxyribonucleic acid (DNA) sequences play a critical role in the onset and progression of cervical
An in-silico meta-analysis of cell-type-specific non-CpG methylation
Nowadays, the amount of raw data required for a genome-wide analysis is quite large and it is often difficult for even its original author(s) to spend enough time for its thorough analysis. Further, it would be practically
Differential diagnosis of neurodevelopmental syndromes using blood episignatures
Neurodevelopmental syndromes refer to a group of inborn diseases that present with impairments of the growth and development of the brain, and facial and somatic dimorphism. The differential diagnosis of these disorders is challenging because of the
Diagnosing Fragile X syndrome by DNA methylation array
Fragile X syndrome (FXS) is the most common genetic condition which causes a range of developmental problems and intellectual disability in males. It is caused by a mutation in the fragile X mental retardation gene (FMR1), which
DNA methylation markers in colorectal cancer state-of-the-art
Colorectal is the fourth leading cause of cancer-related death worldwide. There were over 1.3 million new colorectal cancer cases worldwide, of which approximately 50% died as a result of the disease in 2012. Like all cancers, CRC
Zinc homeostasis in myeloid cells is regulated by epigenetic mechanisms
Zinc is an essential trace element with integral roles in numerous biological processes, including enzymatic function, protein structure, and cell signaling pathways. This metal serves as a catalytic or structural cofactor for about 300 different proteins. Abnormal
How Vitamin C affects the immune system
DNA contains four bases, A, C, G and T (Fig.1). There are 3 billion of these bases in the human genome, and they code for about 22,000 genes. Because each cell carries the same genetic information –
Another prince awakened Sleeping Beauty?
Tumor suppressor genes are one of the body’s defenses against uncontrolled growth of tumor cells. When these genes are ‘silenced,’ or prevented from doing their work, the abnormal cells grow unchecked, usually with fatal consequences to the
A new DNA methylation regulator
CGGBP1 (CGG triplet repeat-binding protein 1) was first identified as a protein that binds unmethylated CGG repeats. It acts as a transcription regulator with target sites at CpG-rich sequences such as CGG repeats and Alu-SINEs (short interspersed
