Tag Archives:disease
BioID screen for bacterial virulence proteins: new tools for infectious disease research
The discovery of penicillin in the 1920s revolutionized our ability to treat bacterial infection. However despite the introduction of antibiotics, infectious bacterial pathogens remain an immense challenge for the healthcare community. The incidence of infection by antibiotic-resistant
The allergies go marching on: the atopic march and the temporal relationship of allergic diseases
Atopic/allergic family of diseases affects >20% of the global population and encompasses allergic asthma, hay fever, food allergy, atopic dermatitis, and allergic rhinitis. Frequently, individuals with an allergic condition develop another allergic disease. The atopic march theory
How to Live With Sickle Cell Disease
Although a diagnosis of sickle cell anemia might be devastating, patients can still live an entirely normal life with the proper care. Patients can live comfortably through treatment and lifestyle changes. Although sickle cell, like other monogenic
Purification and characterization of a better-behaved Alzheimer’s disease protein
Alzheimer’s Disease (AD) is an incurable disease that causes memory, reasoning and thinking to deteriorate over time. AD is marked by brain atrophy and plaque-like deposits of a small peptide called amyloid beta (Aß) outside of brain
Intracranial injections and animal models: towards understanding and treating human disease
The use of laboratory animals helped us to better understand a myriad of biological processes in health and disease and enabled the development of therapies that effectively cure, or ameliorate life conditions of, millions of people every
Macrophage-myofibroblast transition: a novel target for stopping kidney disease
Kidney is one of the major organs in our body for detoxification. Its failure is an important cause of patient mortality that serves as a primary disease and a lethal complication in a range of diseases such
Prevention of congenital heart anomalies: the secret kept by embryonic stem cells
CITED2 is a transcriptional modulator involved in the regulation of the expression of many other genes in vertebrates. At very early stages of embryo development, CITED2 is particularly important for heart formation, a process also termed cardiogenesis.
Exploring the potential of a pneumococcal vaccine to target oxidized LDL in metabolic disease patients
Lipid metabolism involves a wide range of processes in which lipids are processed and used as energy sources, signaling molecules and structural elements of cells. Given its importance, dysfunctions in lipid metabolism, both small and large, can
Upstream open reading frames (uORFs) as translational regulators in human disease
The messenger RNA (mRNA) translation process is a key step of gene expression, whose regulation allows the cell to rapidly change protein synthesis in a spatio-temporal manner in response to different stimuli. Translation comprises four steps –
细胞外的细胞色素c:小说damage-associated molecular pattern (DAMP) of the brain
Cytochrome c (CytC) is a protein that is normally located inside mitochondria where it participates in the energy-generating processes of cells. Since mitochondria are essential for life, these CytC-containing organelles are found in most animal cells. The
Nonsense-mediated mRNA decay (NMD): a bifunctional mechanism in human physiology and disease
Proteins are the working-units of the cell, which are encoded by thousands of genes that pass their information into an intermediate molecule, the messenger RNA (mRNA). For this flow of information – from genes to RNA (transcription),
More than your average bread spread: plant stanols as therapeutical tool in Niemann-Pick type C1 disease
Niemann-Pick type C1 (NPC1) disease is a lysosomal storage disease that affects nearly 1 in 100,000 live births worldwide. NPC1 disease is caused by mutations in the NPC1 gene that result in a dysfunctional NPC1 protein, which
A new strategy for immune manipulation of advanced solid cancers
The biological cancer hallmarks and the current model In the updated ongoing model, genomic instability and inflammation are the basis of all the cancer hallmarks: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality,
Mitophagy in health and disease
Mitochondria are cellular organelles specialized for energy production, and critically influence several features of cellular metabolism and physiology. Maintenance of a healthy mitochondrial pool is a prerequisite for cellular and tissue homeostasis. Compromised mitochondrial function results in
Stem cells and stem cells conditioned medium for inflammatory bowel disease treatment
Inflammatory bowel disease (IBD) is a complex of pathological processes occurring in the intestine. Chemically induced IBD in rodent usually used for study of drug therapy efficacy. Mesenchymal stem cells (MSC) was used as alternative method for
Be careful of podocyte B7-1
Chronic kidney disease (CKD) is a huge global health burden. If not treated promptly, CKD can progress to end-stage renal disease, meaning that kidney function is at below 10% of normal capacity. Under physiological conditions the kidneys
Biomarkers for Alzheimer’s disease diagnosis: an eye on retinal inflammation
Alzheimer’s disease is one of the most common neurodegenerative disorders. Alzheimer’s disease cases are constantly increasing worldwide due to population aging. Typical symptoms of the disease include memory loss, cognitive deficits, personality and behavior modifications. At the
Celiac disease and liver disorders
Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. In celiac disease, increased intestinal permeability is thought to be an early feature in the pathogenesis. Dietary gluten drives intestinal inflammation and impairs the
Vitamin D deficiency is a sign of poor health in chronic obstructive pulmonary disease
Vitamin D is an important hormone in growth and bone metabolism. Vitamin D deficiency is highly prevalent worldwide and causes growth retardation and rickets in children and osteomalacia in adults. However, the role of vitamin D deficiency
Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease
Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million
