Tag Archives:kidney
Macrophage-myofibroblast transition: a novel target for stopping kidney disease
Kidney is one of the major organs in our body for detoxification. Its failure is an important cause of patient mortality that serves as a primary disease and a lethal complication in a range of diseases such
Building an artificial kidney from human stem cells
Many diseases and drugs affect kidney function by damaging the glomeruli — the major site of blood filtration and a target for many diseases. An in vitro model of the human glomerulus could facilitate therapeutic discovery and
Be careful of podocyte B7-1
Chronic kidney disease (CKD) is a huge global health burden. If not treated promptly, CKD can progress to end-stage renal disease, meaning that kidney function is at below 10% of normal capacity. Under physiological conditions the kidneys
The power of urine to understand genetic variants in the kidney
Nephronophthisis is a rare genetic disorder of the kidney and the most common genetic cause of end stage kidney failure in children. It can be caused by mutations in more than 20 different genes. In the 50%
Evolution of the art and science of kidney transplantation in HIV positive patients
Once considered prohibitive, kidney transplantation in HIV (+) recipients is achieving outcomes similar to comparable recipients without HIV. These successes are possible because of incremental improvements in care that resulted from lessons learned from the last two
Kidney function decline in polycystic kidney disease – it’s not always off the cliff
Autosomal dominant polycystic kidney disease (ADPKD) is a relatively common (estimated to affect 1 in 1000 to 1 in 4000 persons all over the world) inherited disorder that leads to kidney failure in the majority of patients
Uremia. A history of urine in the blood
The term uremia was first introduced in 1847; literally translated, it means “urine in the blood.” Today, uremia describes the myriad of symptoms and organ derangements that result from the failure of the kidneys in its normal
Overcome obstacles in the treatment of scarred kidneys
More than 10% of the world’s population suffer from chronic kidney disease (CKD), a serious disorder that leads to a prominent reduction in quality of life and might end fatally. Independent of its initial cause, virtually all
Anti-CD20 treatment shows changes not only in B-lymphocytes but also in T-subpopulations
In renal pathology, Rituximab has been proven to be useful in the treatment of some primary glomerulopathies, vasculitis with renal involvement, severe lupus with kidney disease, and especially in renal transplantation, where it is applied during the
Urea is truly toxic: the empire strikes back
Urea is a metabolic waste product that accumulates in the body in the setting of chronic kidney disease. It is routinely measured on blood tests as a marker of kidney function (higher urea levels indicate lower kidney
A stone during pregnancy – more painful than childbirth
肾或输尿管结石怀孕是一个主要的health concern and are one of the most common causes for abdominal pain in pregnant women. Stones may lead to a blocked kidney, kidney infection which may spread
The capillary web gets lost in diseased kidneys
Main functions of the kidney are regulating ions, pH, fluid balance and blood pressure and disposing of metabolic waste products. These functions are dependent on properly working renal blood vessels, including the smallest ones, the so called
Effect of tenapanor on sodium absorption and interdialytic weight gain in patients with advanced kidney disease
The major function of the kidneys is to eliminate waste products and excess fluid from the body, through the production of urine. Patients with kidney failure need dialysis, typically three sessions per week, as an artificial replacement
Product of red grapes protects kidney from anticancer toxicity by increasing its extruding protein
Cancer chemotherapy is a double-edged tool. At one side, increasing anticancer dose may cure cancer but can cause severe toxic effects to vital organs. At the other side, decreasing the dose can protect vital organs from the
PDGF-D – a potential novel treatment for kidney diseases with scaring
Estimates suggest that a huge number of people, more than 10% of the world-population, are suffering from chronic kidney disease. Chronic kidney disease eventually leads to complete loss of kidney function, which is fatal if not treated
New way to detect kidney injury using keratins
As humans and animals have a skeleton supporting their structure, each cell has a similar microscopic skeleton termed cytoskeleton. Cytoskeleton also helps to maintain the shape and the internal organization of cells and is also involved in
Recent trends in treating kidney stones
Kidney stones are incredibly common in the United States and the prevalence is increasing at a remarkable rate. In the United States, the chance of a man having a kidney stone at some point in his life
Can antioxidants benefit the diabetic kidney?
People who have diabetes are at high risk of developing kidney disease that may require dialysis or transplantation. This has been known for a long time but there is still a need for new ways to prevent
Long-term outcomes of robotic pyeloplasty for ureteropelvic junction obstruction
Ureteropelvic junction obstruction occurs in both adults and children when the ureter (the tube that carries urine from the kidney to the bladder) becomes blocked, preventing the flow of urine out of the kidney. Surgery is often
Nonadherence to immunosuppressive therapy in kidney transplant recipients
End-stage kidney disease (ESKD) is an increasing worldwide illness that compels patients to accept either dialysis or kidney transplantation that is the best choice because ensures high quality of life. But, living or cadaveric kidney donation is
