Yearly Archives:2020
Cryo-electron microscopy in drug development
Cryo-electron microscopy (cryo-EM) is becoming the method of choice in structure determination of membrane proteins and has great potential for structure-based drug discovery (SBDD). Cryo-EM provides high-resolution structural information of a membrane protein without the need for
TMEM165; The Bermuda triangle of glycosylation and Golgi Mn homeostasis
During evolution, eukaryotic cells have acquired a complex network of endomembranes delimiting distinct organelles with specific cellular functions. In mammals, the rough endoplasmic reticulum (ER) and the Golgi apparatus are two key organelles of the secretory pathway
Strong primary healthcare may reduce mortality
Healthcare is variably organized across the world. In some places, people attend medical specialists such as cardiologists and urologists directly. In other places, people attend primary care physicians for most health problems and, if necessary, they refer
Global climate change and mental health
In the past decade, several empirical studies and systematic reviews of the literature have documented the mental health impacts of global climate change. However, the range of impacts and their relationship to specific forms of climate change
Atmospheric and genetic parameters influence Rhinovirus transmission
Rhinoviruses are a diverse set of very small and common viruses, repeatedly infecting humans in the course of a single year. For most people, infection usually results in mild common cold symptoms, and spontaneously resolves without the
Botulinum toxin and occupational therapy for Writer’s Cramp
Dystonia is a neurological disorder characterized by abnormal postures that interfere with making movements. Writer’s cramp is the most common type of dystonia involving the upper extremity. Patients initially experience painless loss of control while writing, discomfort
Can SEM/EDX analysis be useful in prosecution of medical malpractice?
忘记手术以致遭受within a patient’s body after surgery is a serious matter but also sadly known to the newspapers. The retained gauzes may cause severe inflammatory reactions and numerous complications up to death; exceptionally, they can
Targeted GRP78 pathway for improved vision in diabetic retinopathy
糖尿病视网膜病变是糖尿病的并发症s which causes vision loss and eventual blindness in adults. People with diabetes have more sugar in their blood than normal, which causes their bodies not to function correctly. Often proteins
A method for highly sensitive detection of D-amino acids
D-amino acids have recently attracted much attention in various research fields including medical, cliDical and food industry due to their important biological functions that differ from l-amino acid; thus, there has been an increasing need to develop
Nickel free, built-in nanotubular drug eluting stents
Coronary Artery Disease is a common cause of heart failure. Coronary Artery Disease (CAD) is caused by the accumulation of lipids and fats within an injured arteries’ walls and restricts the blood flow to the heart muscle
The suitability of scopolamine as an Alzheimer’s model
Alzheimer’s disease is the most common cause of dementia. About 50 million people worldwide have Alzheimer’s disease or a related form of dementia. Alzheimer’s disease is a terminal illness affecting mostly the elderly above the age of
Imaging metal nanoparticle adsorption on graphene aerogels
The functionalization of porous carbon aerogels and sponge-like materials with metal nanoparticles (NPs) has shown significant promise for several applications, including energy storage and harvesting and environmental remediation. Methods for imaging the internal structure of these porous
Impact of temperature on physicochemical and biological properties of silver-silica nanocomposite
The future of a well-known consumer world seems to be closely related to multifunctional engineering nanomaterials fulfilling a completely new role comparing them with the traditional structures and products. Such materials are inclined to sophisticated applications e.g.
Serum cytokine profile in mice after injection of supernatants of group A streptococci culture
Cytokines are involved in various pathophysiological processes of macroorganism, including regulation of immune response and inflammation. Numerous experiments have demonstrated that cytokines, necessary in small doses, may result in the development of “cytokine storm” when produced in
How mitochondria “sense” and respond to changes in oxygen concentration in vivo
Mitochondria – intracellular organelles – are our organism’s “powerhouse”, the main oxygen sensors that play the signaling role as modulators of oxygen consumption and regulators of the rate of oxygen delivery from the extracellular environment. Changes in
How can we measure problematic videogame use among adolescents?
Playing video games is currently one of the most frequent leisure activities in young people and adolescents, but it generates a social alarm because it is associated with negative consequences such as family or scholar problems, reduction
Strengthening the Paris Agreement by supply-side climate policies
To reach the Paris Agreement’s goal of keeping global warming well below 2 degrees, much of the world’s deposits of oil, gas and coal must be left permanently in the ground. In an article published in Science
Why photobiomodulation therapy is helpful for diabetic wound healing? Fibroblast answers!
It is an obvious well-known issue that diabetic wounds are poorly healing, but the molecular and cellular alterations leading to this impairment is not clear. Many studies concluded the dysfunction of dermal fibroblasts as the main responsible
Modulating the distribution and fate of MSCs following therapeutic delivery may enhance their efficacy
Mesenchymal stem/stromal cells (MSCs) can be isolated from multiple adult tissues and have been shown to produce factors which can protect cells from diverse injurious stimuli, favourably modulate the immune response, and enhance tissue reparative and regenerative
The roles of mesenchymal stem cells secretome in diabetic wound healing
There has been a fourfold rise in the number of diabetics from 108 million in 1980 to 422 million in 2014 and by 2040 the number will reach to 642 million. Diabetes mellitus drastically influences normal functioning
