Monthly Archives:November 2019
Truncation: A possible mechanism for diversity in Alpha-synuclein prion-like properties
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, which is characterized by motor disturbances such as tremor and bradykinesia resulting from severe degeneration of nigral dopaminergic neurons. The pathological hallmark of PD is the presence
Using controlled disorder to probe coexisting quantum orders in NbSe2 superconductor
Many pure elements and complex compounds become superconducting when their electrical resistance drops to zero below critical temperature, Tc. For more than a century, the race for higher Tc remains one of the most exciting topics in
Educational hospitalization for ulcerative colitis: relapse prevention by plant-based diet
Inflammatory bowel disease (IBD) is a collective term for ulcerative colitis (UC) and Crohn’s disease (CD). IBD is no longer a disease mainly seen in Europe and North America and is now a global disease. The disease
Erythropoietin can improve urethral healing
The most important problem of urethral wound healing is an increase in abnormal fibrosis because of imbalances in the healing processes. Healing of traumatic or idiopathic wounds in the urethra is known to be complicated and a longer process
Ca2+ dynamics and allosterism in synergistic action between Beta2-adrenergic agonists and muscarinic antagonists
G proteins (Gs, Gi)/large conductance Ca2+-activated K+ (KCa) channels/L-type voltage-dependent Ca2+ (VDC) channels linkage (Ca2+ dynamics) may play key roles in β2-adrenergic relaxation and muscarinic contraction in the airways. β2-Adrenergic receptor agonists and muscarinic receptor antagonists are
Estimating daily evaporation from poorly monitored lakes using limited meteorological data
Estimating water evaporation is vital in many problems that are related to agriculture, hydrology and lake operation planning. In fact, water loss by evaporation from rivers, lakes and open reservoirs is a crucial problem in regions that
短暂的Post-Coma规模(bpc):一个简单的工具assess responsiveness in disorders of consciousness
The Brief Post-Coma Scale (BPCS) is an easy diagnostic tool to differentiate patients with disorder of consciousness in the minimally conscious state (MCS) from those in unresponsive wakefulness syndrome (UWS), formerly defined as vegetative state (VS). The
How to build great AI
Even though artificial intelligence (AI) is in full bloom and more and more businesses are developing their own solutions, there are several things around it that aren’t quite clear. One of the most pressing ones is what
Osteoarthritis alleviation by rewiring cellular energy metabolism
Osteoarthritis (OA) is a chronic disorder associated with degeneration of the joint, including articular cartilage, subchondral bone, synovial tissue, tendons, periarticular muscles that involves low-grade systemic inflammation. Recent studies have demonstrated the involvement of chondrocyte differentiation (hypertrophy)
Mitochondrial dysfunction in autism spectrum disorder
Autism spectrum disorder (ASD) affects ~2% of children in the United States. The etiology of autism spectrum disorder likely involves environmental factors triggering physiological abnormalities in genetically sensitive individuals. One of these major physiological abnormalities in children
5 Tips for Outsourcing Scientific Software Development
Outsourcing your scientific software development projects can yield great benefits for your company, including reduced costs, increased flexibility, and improved product quality. If you choose to go this route, outsourcing should be approached deliberately. First, take steps
How we can curb deaths from heroin use
Evidence from many countries shows an alarmingly high death rate amongst former prisoners with histories of heroin addiction in the two weeks following their prison release. A heroin overdose is the most common cause of death in
What can we achieve for average spin Hamiltonians in solid-state nuclear magnetic resonance spectroscopy?
Multiple-pulse sequences (MPS) have been widely applied in nuclear magnetic spectroscopy to manipulate spin Hamiltonians (such as isolating or enhancing certain interactions while removing the effects of all other interactions), to measure relaxation times, and to enhance
Nailfold microangiopathy in dermatomyositis and systemic sclerosis: what is different in long term follow-up?
Dermatomyositis (DM) is a chronic inflammatory disorder involving mainly the skin and muscles. Systemic Sclerosis (SSc) is an autoimmune rheumatic disease of unknown etiology characterized by vascular alterations and progressive tissue fibrosis of multiple organs. Peripheral microangiopathy
Effects of nitric oxide donation and nuclear factor-kappa B inhibition on schistosomiasis mansoni
Schistosoma chronically infects millions of people worldwide, and is considered an important cause of liver fibrosis; a reversible wound healing that reflects a balance between liver repair and scar formation, and is mainly maintained by chronic activation
Driving time delays treatment initiation for tuberculosis in Uganda
We investigated the association between distance to health care facilities and delay in treatment initiation for patients with tuberculosis in Kampala, Uganda. We used a theoretical construct known as appraisal delay, which is the approximate time in
Understanding the behavior of fly larvae from neural activities in their isolated central nervous system
You may have heard about “The brain in a vat”, the philosophical scenario which talks about simulated reality and conceptions. It may sound bizarre and unrealistic. However, larval fruit fly neuroscientists literally perform the experiment to understand
Does intestinal inflammation impact the lung response to bacterial endotoxin?
Lung inflammation leading to airway hyperresponsiveness causes illnesses for more than ten percent of the population in USA. Recent research had indicated that patients with inflammatory bowel disease have higher incidence of airway hyperresponsiveness compared to the
Understanding painful sex
Feeling severe pain while trying to have intercourse is one of the worst experiences that can occur in a sexual relationship. The most frequent cause of such pain is felt immediately upon penetration, i.e. at the entrance
Topical treatments for actinic keratoses: the bill, please!
Actinic Keratosis (AK) is a cutaneous pre-malignant lesion presenting with a scaly and reddish patch or plaque. It is caused by chronic ultraviolet light exposure, therefore, it affects most often sun-exposed areas of the body and is
