Tag Archives:signalling
Zinc promotes myoblast differentiation activating Zip7 transporter and Akt signalling pathway
Skeletal muscle is a heterogeneous, dynamic and plastic tissue, which comprises 40% of adult human body mass. Through contraction and relaxation, skeletal muscles provide movement and stability to the body. Besides the mechanical function, muscle tissue also
Expression of mTOR-signalling pathway proteins in skin squamous-cell carcinomas before and after conversion to mTOR-inhibitors
Inhibitors of the Mammalian Target of Rapamycin (mTORis) are drugs exerting both immunosuppressive and antitumor effects, and are thereby used in organ-transplant recipients (OTR) in order to both prevent allograft rejection and to reduce the risk of
A dual specificity protein phosphatase and redox homeostasis in plants
Man has been struggling to understand and define life since the day he became aware of it. Innumerable philosophies and findings over the history of mankind together draw the perspective with which we look at life today.
How to build a communication system for cells
Single cell organisms, such as amoebae, are able to live independently without the need for extracellular communication systems. However, multicellular organisms, such as insects, fish and mammals, require systems that permit individual cells to communicate to one
The variegated world of poly-ubiquitin chains
Proteins share with living beings the events of birth, life and death. They are ‘born’ when information contained in the DNA is translated into an amino acid chain and live their life in their natural environments (i.e.
Demyelination and remyelination signalling in multiple sclerosis as an aid to targeted therapy
Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) characterised by demyelination. Demyelination, i.e. damage and erosion of the myelin sheath which protects the nerve fibres, occurs in the white matter of
Trafficking and signalling from the endosome regulate blood vessel formation in the lung
The formation of new small blood vessels is essential during development and as a repair mechanism in disease. In the lung, blood vessel formation is altered in diseases such as severe bacterial infection and tumour spread. The
