Tag Archives:tumor
Curing glioblastoma with oncolytic virus and immune checkpoint blockade
Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint
Tumors of the pituitary and headache: Will it get better after surgery?
Headaches belong to the most common neurological common disorders, with many patterns of presentation, ranging from acute to chronic. Globally, the World Health Organization (WHO) estimates that half of the world’s population suffers from headache at least
The mechanisms of MCP-1 production in tumor microenvironments: Tumor cells are not home alone
When you look at tumors, you may think they are composed of 100% tumor cells. The fact is that tumor tissues contain not only tumor cells but also a variety of non-tumor stromal cells, including fibroblasts, endothelial
Osteosarcoma – lost in translation
A 16-year-old boy with pain around the knee of two months’ duration demonstrates a lesion in the epiphysis of the distal femur (long bone). The differential diagnosis may be broad, but the pathologist is able to achieve
Pedophilia emerging in a 64 years old pediatrician
Everyone knows what pedophilia is, but probably only few people are aware that pedophilia might also emerge anytime in life as a consequence of brain damage. Indeed, sometimes pedophilic behavior could be observed in old people with
Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies
Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the
Is the best cancer offense a good defense?
Although the unique DiRas (Distinct subgroup of the Ras family) family of small GTPases shares homology with the pro-oncogenic Ras GTPases, it has tumor-suppressive actions. DiRas1 (also known as Di-Ras1 or Rig) has been reported to be
Lessons learned from the study of non-cancerous meningioma tumors
Meningiomas are the most common among tumors inside the skull (35.6%). The cellular origin of these tumors is the membrane that surrounds the brain, the meninges (Fig. 1) Most meningiomas are grades I & II according to
A new test to select more effective treatments for lung cancer
Sadly, the majority of patients with Lung Cancers who cannot be treated by surgery to remove their tumour, die within a few years. Small numbers are beginning to benefit from chemotherapies which target very specific types of
Less is more for staging vaginal cancer
Criteria for predicting the survival of women with vaginal cancer has been established by physician specialists trained in treating gynecologic cancers in the United States and around the world. The current 5-year overall survival is approximately 74%
Tumor risk from low-dose radiation exposures with the example of dental diagnostic X-ray
It was reported that exposure to dental diagnostic X-rays in oral, dental and maxillofacial care increases the risk of benign tumors (meningioma), but not of malignant brain tumors (glioma). Malignant gliomas grow more rapidly. Meningioma, a benign
Atomic classification of cancer cells
Cancer cells have molecules, known as receptors, on their surface that distinguish them from healthy cells. Knowing receptors that are present on malignant cells can help to detect and/or classify the disease. Here, we developed a method
A “TORgeted” way to heal the gut
Our intestine is critical for absorbing the dietary nutrients that we need to survive. It performs this function by producing, from pools of intestinal stem cells (ISCs), a constant stream of new cells (differentiated cells) that have
Fluorescent carbon dots integrated hydrogels for lung cancer therapy
Cancer is considered as one of the leading cause of death worldwide. Due to the ever changing lifestyle of the modern society, the incidence of cancer is on the rise. Lung cancer is the most frequently diagnosed
Nanoscintillators: magic internal light sources to assist radiotherapy
Photosensitizers are molecules that are able to produce cytotoxic species that include singlet oxygen, a particular form of oxygen that is strongly oxidizing, when they are illuminated by visible or NIR light. Because of this property, they
Is our immune system mistaking tumours for foetuses?
Tumours are abnormal growths of tissue where cells produced by the body get out of control and divide at a rapid and unregulated pace. And – when you think about it – embryos too are masses of
Improving nature’s own communication system to fight cancer
Our bodies are composed of trillions of different cells, which communicate with each other in order to keep us healthy. There are several ways in which messages can be sent back and forth between cells. One of
Heat shock protein as a novel druggable target in angiogenesis?
Angiogenesis is a physiological process that involves formation of new blood vessels from pre-existing vessels for efficiently providing oxygen and nutrients during growth and development, as well as during wound healing. Under pathological conditions, angiogenesis is regulated
Treatment holidays for patients with metastatic kidney cancer
Targeted therapy is the standard treatment of patients with metastatic cancer of the kidney. The best current therapies target the tumour vasculature thereby blocking the access of the tumour to nutrients and limiting possibility of spreading to
Emergency department presentation predicts poor outcomes after meningioma removal
A meningioma is one of the most common forms of a brain tumor. Unlike many other types of brain tumors, meningiomas are typically associated with relatively favorable outcomes even when they require surgical treatment. In the past
