Monthly Archives:October 2022
Short hydrogen bonds in proteins and their quantum mechanical nature
The assembly of linear polypeptide chains into functional three-dimensional protein architectures involves a unique force called hydrogen bonding. A typical hydrogen bond forms when the donor and acceptor groups approach each other with a nearly linear geometry
Modulation of intracellular dopamine signaling by aripiprazole may cause malocclusion as an extrapyramidal symptom
Aripiprazole, a dopamine partial agonist, is one of the most widely prescribed atypical antipsychotics and its use in children and adolescents has become common. However, due to its favorable side effect profile, its potential for inducing extrapyramidal
Role of dopamine in cortico-basal ganglia loop in psychosis
Dopamine plays a major role in the formation of acute psychosis, as indicated by the dopamine hypothesis of schizophrenia. The relationship between acute psychosis and the dopamine system provides insight into the effects of dopamine on brain
Defects in mismatch repair increase cancer risk and influence treatment selection
Microsatellites are formed by 1-6 nucleotide base pairs that are repeated in direct order 5-50 times. Repetitive DNA including microsatellites are mainly present in non-coding DNA regions that occupy more than 97% of the nuclear DNA. They
Is milk and meat from the offspring of a bull genome edited to have no horns safe to eat?
Horns on cattle are an animal welfare and human safety concern, but most high producing dairy breeds grow horns. Introducing the polled (hornless) trait into the dairy population by crossbreeding would also introduce non-productive traits by linkage
The Genetic Medicine Revolution — Eyes on the Future
Is the genetic revolution everybody talked about in 2001 after the human genome sequencing, here already? History and Background: It is astounding that as early as the 1960s, scientists speculated that DNA sequences could be introduced into
Postponed protonation under competitive conditions in rhodium catalyzed domino reactions
The readily available α,β-unsaturated compound (Michael acceptor) serves as one of the most important building blocks in synthetic chemistry, which is widely used in conjugate addition reaction. The characteristic of conjugate addition reaction is that it is
