Monthly Archives:November 2015
Using cheminformatics to aid in the discovery of new drugs
Finding new medicines is a difficult and expensive endeavor and grows more difficult and expensive with every passing year. Thus, new ways to streamline the process are desperately needed by the pharmaceutical industry. Once upon a time,
Mutations in the gene DLL4 cause Adams-Oliver syndrome
Adams-Oliver syndrome (AOS) is a rare hereditary disorder that occurs in 1 in 225.000 individuals and is characterized by the presence of both scalp and limb defects. Congenital anomalies of the heart and blood vessels are also
Kidney disease dramatically affects whether patients should undergo vascular interventions
Kidney disease is a significant risk factor for poor outcomes following vascular surgery, and should be taken into consideration when evaluating patients for elective vascular interventions. Patients with kidney dysfunction who are recommended intervention by a vascular
Gelatin composites for controlled release of actives
During the 1950s the pharmaceutical market was flooded with oral products promising a prolonged release of actives. Since then a constantly growing effort has been devoted to the design of materials and formulations able to spatially and
Regular physical activity protects against depression after myocardial infarction
Depression is common and estimates suggest that in a family of four, one of the family members will likely suffer from mental health problems. Depression is even 3 times more common in patients after a heart attack
A method for studying mouse mammary tumorigenesis
Metastasis is the last step of primary breast cancer progression in which cells from the primary tumor leave and go to other organs. Breast cancer cells often metastasize to the lung, among other organs. Each step in
Psychological distress during and after the armed conflict in Burundi
Armed conflicts can have important and long lasting effects on the physical and mental health of people exposed to the. Especially in low and middle-income countries where not only the majority of conflicts take place but also
Color is not the whole story – varieties of deep purple sweet potatoes and their health properties
Purple plant foods (e. g. purple cabbage, purple cauliflower, blueberries) contain high amounts of anthocyanins, which are antioxidants responsible for the strong blue – purple colors. There are > 500 different anthocyanin molecules, some of which have
Bioactive properties of milk proteins in humans
The importance of the diet in human health has been recognized for centuries. Milk is the primary source of nutrients for infants. It provides a nutritionally balanced source of both macronutrients (proteins, fats and carbohydrates) and micronutrients
Fit rats can stomach menopause
Women enter menopause when their ovaries stop making the hormone estrogen. The longer a woman is postmenopausal (without estrogen), the more likely she is to gain weight and fat storage moves from the hips and thighs to
破坏性的行为可以观察到从1½5岁years predict children’s adjustment in first grade?
Disruptive behaviors (DB) embedded in psychiatric’ Diagnostic Statistical Manual (DSM) categories of Attention – Deficit/Hyperactivity Disorder ( ADHD ), Oppositional Defiant Disorder ( ODD ), and Conduct Disorder ( CD ) are the most frequent behavior disorders
A relationship between Idiopathic Adolescent Scoliosis and motion sickness
Advances the understanding of this disease? Adolescent idiopathic scoliosis is a three-dimensional deformity of the spine observed in 2 % of the adolescent population aged 10–16 years (Fig 1A). It is a serious medical condition, susceptible of
How to improve outcome in patients with primary appendiceal mucinous cancer
Appendiceal mucinous cancers are extremely rare cancers. The management of mucinous appendiceal tumors is mainly based on single-institution experiences. A challenge in the treatment of this disease is that a large number of patients present with disease
Bureaucrapathologies
Although regulatory bureaucracies are necessary to perform society’s business, these institutions frequently display dysfunctional organization patterns that interfere with efficient and effective conduct of the work they are presumably supposed to accomplish. We have coined the whimsical
Digging out self-assembly process of molecules by scanning tunneling microscopy
Molecules are known to spontaneously self – assemble into supramolecular structures in solution, on surface, and also at interface. An appropriate understanding of the process of self – assembly is of critical importance to make sophisticated nanostructures.
Why does BCG fail to protect against tuberculosis?
Mycobacterium tuberculosis (M.tb) is the microbe that causes tuberculosis (TB), a disease that kills one human every 18 seconds. In the last 80 years, only one vaccine has proven somewhat effective at preventing the development of TB
Chloroquine inhibits the malignant phenotype of glioblastoma
Glioblastoma (GBM), the most common and aggressive primary brain tumor, is characterized by excessive growth and infiltration of the normal brain which prevents the complete surgical resection. These tumors also are refractory to standard treatment strategies, which
Another beneficial role for insulin in the brain: keeping the brain immune responses in check
大脑disease is an umbrella term, which is used to describe a broad variety of diseases ranging from epilepsy to Alzheimer’s disease to multiple sclerosis and everything in between. Brain diseases differ from each other at the
Uncovering mechanisms underlying Parkinson’s disease pathology
Parkinson’s Disease (PD) is a severely debilitating motor disorder characterized by loss of dopaminergic neurons and an increase of α-synuclein in a brain region known as the substantia nigra pars compacta (SNpc). Although much progress has been
What is the quality of our river ecosystems? The new emerging stressors
An ecosystem is a dynamic complex of plant, animal and micro-organism communities and their non-living environment interacting as a functional unit (e.g. coral reefs, wetlands, rainforests, boreal forests, cultivated farmlands). The Ecosystem services are the benefits that
